Desitin Maximum Strength Baby Diaper Rash Cream, 40% Zinc Oxide for Treatment, Relief & Prevention, Hypoallergenic, Phthalate- & Paraben-Free Paste, Protects Skin For Up To 12 Hours, 16 oz

A household essential that heals fast and protects even better Desitin Maximum Strength Diaper Rash Cream has been around for decades for a reason—it simply works. The 40% zinc oxide formula is thick, soothing, and forms an instant protective barrier that seals out moisture and promotes healing. It’s the go-to for stubborn rashes that other creams can’t touch, often clearing irritation within a day or two. The cream’s texture is dense but spreads evenly, staying in place through multiple diaper changes or overnight use. It’s gentle enough for newborns yet strong enough for adults dealing with chafing or skin irritation from incontinence pads, sweat, or friction. Because it’s hypoallergenic and free of parabens, phthalates, and dyes, it rarely causes irritation even on sensitive skin. The 16-ounce tub is great value—it lasts for months and is far more economical than small tubes. The only minor drawback is that the paste can be hard to remove completely from skin or fabric if overapplied, and it has a mild medicinal scent that not everyone loves. Bottom line: a trusted, dermatologist-tested classic that lives up to its reputation. If you need fast, reliable relief for diaper rash, chafing, or general skin irritation, Desitin Maximum Strength remains the gold standard for both babies and adults alike.

This is great stuff and often the only thing that works for minor annoying thingies. My dermatologist 's recommendation . However, Walmart has their own brand of 40% zinc oxide (which is what this is) at 1/5th the price. Ah, the price of advertising.

Desitin Maximum Strength Diaper Rash Cream is a lifesaver for my baby’s sensitive skin. It works fast — I noticed a big improvement after just one or two diaper changes. The thick formula creates a strong barrier that protects against moisture and irritation, and it stays in place really well. A little goes a long way, so the tube lasts quite a while. The smell is mild and pleasant, and it gives me peace of mind knowing my baby is comfortable and rash-free. Definitely a must-have for every diaper bag!

-Desitin Maximum Strength Paste is a staple for our baby’s sensitive skin. The 40% zinc oxide formula provides an excellent protective barrier that isn’t too thick. In our experience, it makes rashes disappear in 1-2 uses. It is extremely reliable and we don’t leave the house without it. We prefer this concentration to the 13% zinc oxide (blue label). We don’t leave the house without it and the 16oz tub provides excellent value.

Works exactly how it should. Thick, protective ointment that stops and soothes diaper rash fast. A little goes a long way, doesn’t sting, and stays put through messy changes. Reliable diaper-bag staple every parent should have.

This jar lasted just about a year. Great for prevention but also helps with healing. Not too easy to get off your hands

This is the only product that helps my baby skin when she has diaper rashes. The price for the amount of product worth but its too big and hard to carry.

Desitin Maximum Strength has been my go-to diaper rash cream for years, and it continues to be one of the most effective options I’ve tried. The thick, rich formula with 40% zinc oxide creates a strong barrier that protects the skin and starts soothing almost immediately. It’s especially helpful during overnight changes or when my baby has a particularly irritated rash—it noticeably reduces redness and discomfort by the next diaper change, often within hours. I like that it’s hypoallergenic and free from added parabens and dyes, which gives me more confidence using it on sensitive skin. There’s a noticeable difference in how quickly rashes clear up compared to milder creams. It’s definitely on the thicker side, so it takes a little more effort to spread and remove, but that’s also what makes it so effective—it stays in place and doesn’t wear off too quickly. The 4.8 oz tube is a generous size and lasts quite a while, even with regular use. It’s also a good size to keep in the diaper bag without taking up too much space. If you're dealing with anything more than mild irritation, this is the kind of product that actually makes a difference. It’s not fancy, but it’s reliable, safe, and it works—which is exactly what I want in a diaper rash cream.